My new doctor switched me from OrthoTri Cylen (on it for 13 years was perfectly happy on it) to Desogen and I took the generic (Apri) and I have since gained around 10lbs over the last 2 years. I stopped exactly 3 weeks ago today and I have lost 3 lbs. I will never ever go back on it. Coincidetally I have recently learned that it may cause blood clots in your lungs and legs. I know that's a risk of BCPS but the 3rd generation brands seem to be the culpirts. I would stay away from Desogen but the other poster is right they affect people differently.