I was on Alesse for over two years and never had acne in my life. Then I stopped it for about 3 months cause it made me gain weight and I wanted to lose some. That is when my face started breaking out really bad. I went to the derm. and he put me on Doxy, Klaron, Differin and Yasmin. I started them all at the same time so I really don't know which one worked the best. Well it has been 2 years of consistent use of all of those. My derm. wanted me to stop Doxy. so I still use everything else just not that. That is when this itching started. Last night I used the Differin but I applied less and guess what no itching today? Maybe I have just been overdoing it on the topicals? I don't know guess we will see........