It really depends on the individual, but from my 1 year experience with Ortho Tri-Cyclen it actually made things worse for me. I've been on Desogen for about 10 months now and I love it. My skin looks much better, and my periods are really light and only last, like, 3 days. I don't have any breakthrough bleeding problems like I did when I started on BC with Alesse. Just my two cents, I'd go for the Desogen. Plus, it's monophasic, so if you need to skip a period you can do that with Desogen.