Yes my fried actually used Sulfacet R at nite and the klaron during the day(easy to wear under makeup) and it copletely wiped her zits away...I;m uisng just teh Klaron i take ALesse bith control pills..tried Orthtricyceln made my acne worse and i was taking 100-200 mg of Minicyceln but i ahd been on antibiotics for so many yrs for acne prior that i'm immune to them now..