I looked up some info about this subject. This is the only case where I found any mention of depression. Also, keep in mind that spiro is a diuretic, which means that if you are not drinking enough water while taking it, you could simply be dehydrated and feeling weak or tired because of that, which might look like depression, but isn't. See below under "comments".

Spironolactone
Brand Name Manufacturers
Aldactone by Searle
Spironolacton by ? in Bulgaria
Uractone by ? in Italy
Verospiron by ? in Hungary

Generic Manufacturers

Caremark
Cheshire
Geneva
Goldline
Heartland
Major
Moore, H.L.
Mutual
Mylan
Parmed
PD-RX
Purepac
Qualitest
Raway
Rugby
UDL
URL
Vanguard

Pharmacology
Mostly inhibits production of testosterone at the stage of 17-hydroxylation, and competes with DHT (dihydrotestosterone) for bonding at peripheral receptors. It is also said to intensify catabolism of androgens, and activate conversion of testosterone into estrogens.

Delivery
25, 50, 100mg oral tablets

Typical dosage
Pre-op 100-400mg/day
Post-op 50mg/day

Availability
Approved by U.S. FDA

Indications
Congestive heart failure. Elevated blood pressure. Fluid retention. Hyperaldasteronism. Inadequate pottasium retention. Liver cirrhosis.

Contraindications
Elevated potassium levels. Inadequate urine production. Kidney disfunction.

Adverse reactions
CNS

Confusion. Dizziness. Drowsiness. Headache. Lethargy. Loss of precise motor control.

Gastrointestinal

Cramping. Diarrhea. Dry mouth. Gastric ulceration and other stomach inflammation. Vomiting.

Skin

Acne. Itchy, fluid-filled patches of skin. Increase of body and facial hair. Red skin patches from capillary congestion.

Other

Deepening of the voice. Drug fever. Pottasium retention. Severe decrease of blood granulocytes. Sodium loss.

Comments
One person reported suicidal depression as an adverse effect. The brand-name formulation tastes awful; the generic formulation is much less offensive.