Those of you who have/had taken very large daily doses of opiates that contain acetaminophen ("apap", Tylenol, etc)...I've always wanted to ask -- have any of you had liver problems? When I first started posting and recognizing I had a bad Norco problem, I made sure I didn't go over 4,000mg a day (of the apap) but some of you say you take really high doses and I've been curious about that.

Of course if you take opiates with no apap, that's different.

As always, am asking with no judgments, just wondered.